Prefoldin subunits (PFDN1–6) serve as poor prognostic markers in gastric cancer

CD44 Variant 9 Serves as a Poor Prognostic Marker in Early Gastric Cancer, But Not in Advanced Gastric Cancer.

PURPOSE The present study is to investigate the significance of CD44 variant 9 (CD44v9) expression as a biomarker in primary gastric cancer. MATERIALS AND METHODS With various gastric tissues, we performed immunohistochemical staining for CD44v9. RESULTS The positive expression rates for CD44v9 in tumor, including adenoma, early gastric cancer (EGC), and advanced gastric cancer (AGC), were ...

Prognostic significance of tumor markers in T4a gastric cancer

BACKGROUND The clinical importance of preoperative tumor markers remain elusive in gastric cancer. The aim of this study was to evaluate the prognostic value of AFP, CEA, CA19-9, and CA50 in T4a stage gastric cancer. METHODS Two hundred and seventy-three T4a gastric cancer patients who underwent curative D2 gastrectomy between 1996 and 2005 were evaluated. The correlation between tumor marker...

Cancer Stem Cell Markers CD44, CD133 in Primary Gastric Adenocarcinoma

Cancer stem cells (CSCs) are unique subpopulations that have the capacity to drive malignant progression with renewal abilities. Recently the role of some of CSCs in gastric adenocarcinoma has been studied. This study was performed in order to evaluate CD44 and CD133 expressions by immunohistochemistry in 95 primary gastric adenocarcinoma and their relation to clinical and pathological paramete...

Helicobacter pylori and Molecular Markers as Prognostic Indicators for Gastric Cancer in Korea

BACKGROUND The prognosis of H. pylori infection-negative gastric cancer (HPIN-GC) has been rarely investigated. Applying a strict definition of H. pylori status, the prognosis and molecular prognostic markers in HPIN-GC were evaluated. METHODS A combination of multiple methods was carried out to strictly evaluate H. pylori infection in gastric cancer (GC) patients between June 2003 and Octobe...

Tumour Markers as Prognostic Factors of Survival of Gastric Cancer Patients